bothrops jararaca การใช้

• One case has been reported in the " Bothrops jararaca " snake with a dead South American rattlesnake.
• Captopril is based on the peptidic bradykinin potentiating factor ( BPF ) isolated from venom of the Brazilian arrowhead viper ( " Bothrops jararaca " ).
• Brazilian scientist S閞gio Henrique Ferreira reported a bradykinin-potentiating factor ( BPF ) present in the venom of " Bothrops jararaca ", a South American pit viper, in 1965.
• To show this approach works, Harrison's team took the gene for jararhagin, a deadly enzyme in the venom of the Brazilian pit viper ( Bothrops jararaca ) that causes hemorrhaging.
• For example, teprotide, a peptide isolated from the venom of the Brazilian pit viper " Bothrops jararaca ", was a lead in the development of the antihypertensive agents cilazapril and captopril.
• BPF was later found to be a peptide in the venom of a lancehead viper " ( Bothrops jararaca ) ", which was a  collected-product inhibitor of the converting enzyme.
• For example, botrocetin, found in the venom of Bothrops jararaca, activates von Willebrand factor ( vWF ) by inducing it to bind to platelet glycoprotein Ib ( GPIb ) thereby providing the surface for initial platelet aggregation.
• The substance, a short kinin with nine amino acids only, was detected in the blood plasma of dogs after the addition of venom extracted from the " Bothrops jararaca " snake, brought by Rosenfeld from the Butantan Institute.
• While it's true that some high blood pressure drugs were developed from natural products ( like ACE inhibitors from the venom of Bothrops jararaca ), I can find no mention that these substances were used medicinally before the heavy research done starting in the 1950s.